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Article

Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.

Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2016

Tukachinsky Hanna, Petrov Kostadin, Watanabe Miyako, Salic Adrian

Abstract excerpt

The Hedgehog cell-cell signaling pathway is crucial for animal development, and its misregulation is implicated in numerous birth defects and cancers. In unstimulated cells, pathway activity is inhibited by the tumor suppressor membrane protein, Patched. Hedgehog signaling is triggered by the secreted Hedgehog ligand, which binds and inhibits Patched, thus setting in motion the downstream events in signal...

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Identifiers

PMID: 27647915
DOI: 10.1073/pnas.1606719113
PMCID: PMC5056095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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