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Article

Derivation of diabetes-resistant congenic lines from the nonobese diabetic mouse.

Clinical immunology (Orlando, Fla.) - 1 Aug 2000

McDuffie M

Abstract excerpt

Autoimmune diabetes is a polygenic disease process in man and rodents. To identify and characterize genes involved in the pathogenesis of diabetes in nonobese diabetic (NOD) mice, we initiated a repetitive backcross of diabetes-resistant C57L/J mice onto the NOD strain. This breeding scheme was based on the premise that selection for the trait of disease resistance among genetically mixed mice could be used to...

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Identifiers

PMID: 10900159
DOI: 10.1006/clim.2000.4893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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