A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.

doi:10.2337/diabetes.52.1.218

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.

Diabetes - 1 Jan 2003

Brodnicki Thomas C, Quirk Fiona, Morahan Grant

Abstract excerpt

The nonobese diabetic (NOD) mouse is genetically predisposed for the spontaneous development of type 1 diabetes. Linkage analyses have identified at least 19 susceptibility loci (Idd1-Idd19) that contribute to disease pathogenesis in which lymphocytes mediate the specific destruction of insulin-producing beta-cells. Interestingly, nondiabetic mouse strains have been shown to confer susceptibility alleles to...

Topics

Alleles
Animals
Animals, Congenic
Chromosome Mapping
Diabetes Mellitus
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Heterozygote
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, Inbred Strains
Time Factors

Source

Open in PubMed

Identifiers

PMID: 12502517
DOI: 10.2337/diabetes.52.1.218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics