Article
Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 1996
Yui M A, Muralidharan K, Moreno-Altamirano B, Perrin G, Chestnut K, Wakeland E K
Abstract excerpt
Insulin-dependent (Type 1) diabetes (IDD) in the NOD mouse is inherited as a complex polygenic trait making the identification of susceptibility genes difficult. Currently none of the non-MHC IDD susceptibility genes in NOD have been identified. In this paper we describe the congenic mouse approach that we are using for the dissection of complex traits, such as IDD. We produced a series of six congenic strains...
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