Article
Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis.
Immunogenetics - 1 Aug 2014
Wang Nancy, Elso Colleen M, Mackin Leanne, Mannering Stuart I, Strugnell Richard A, Wijburg Odilia L, Brodnicki Thomas C
Abstract excerpt
The nonobese diabetic (NOD) mouse strain serves as a genomic standard for assessing how allelic variation for insulin-dependent diabetes (Idd) loci affects the development of autoimmune diabetes. We previously demonstrated that C57BL/6 (B6) mice harbor a more diabetogenic allele than NOD mice for the Idd14 locus when introduced onto the NOD genetic background. New congenic NOD mouse strains, harboring smaller...
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