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Article

A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2018

Huang Wenting, Rainbow Daniel B, Wu Yuehong, Adams David, Shivakumar Pranavkumar, Kottyan Leah, Karns Rebekah, Aronow Bruce, Bezerra Jorge, Gershwin M Eric, Peterson Laurence B, Wicker Linda S, Ridgway William M

Abstract excerpt

We previously reported that NOD.c3c4 mice develop spontaneous autoimmune biliary disease (ABD) with anti-mitochondrial Abs, histopathological lesions, and autoimmune T lymphocytes similar to human primary biliary cholangitis. In this article, we demonstrate that ABD in NOD.c3c4 and related NOD ABD strains is caused by a chromosome 1 region that includes a novel mutation in polycystic kidney and hepatic disease 1...

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Source

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Identifiers

PMID: 29158418
DOI: 10.4049/jimmunol.1701087
PMCID: PMC5757511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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