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Article

Evaluation of the effects of 20 nonsynonymous single nucleotide polymorphisms of CYP2C19 on S-mephenytoin 4'-hydroxylation and omeprazole 5'-hydroxylation.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2011

Wang Huijuan, An Nianzhen, Wang Hao, Gao Yiwen, Liu Duan, Bian Ting, Zhu Juanli, Chen Chao

Abstract excerpt

CYP2C19 is a highly polymorphic enzyme that affects the metabolism of a wide range of therapeutic drugs. Almost all the identified alleles of CYP2C19 are derived from nonsynonymous single nucleotide polymorphisms (nsSNPs). The objective of this study was to functionally characterize 20 nsSNPs of CYP2C19, distributed throughout the entire coding region, most of which have not been thoroughly characterized. cDNAs...

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Identifiers

PMID: 21325430
DOI: 10.1124/dmd.110.037549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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