Article
Genetic analysis of the human cytochrome P450 CYP2C9 locus.
Pharmacogenetics - 1 Oct 1996
Stubbins M J, Harries L W, Smith G, Tarbit M H, Wolf C R
Abstract excerpt
Cytochrome P450 CYP2C9 metabolizes a wide variety of clinically important drugs, including phenytoin, tolbutamide, warfarin and a large number of non-steroidal anti-inflammatory drugs. Previous studies have shown that even relatively conservative changes in the amino acid composition of this enzy...
Topics
- Alleles
- Aryl Hydrocarbon Hydroxylases
- Codon
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 Enzyme System
- DNA Primers
- Gene Frequency
- Humans
- Molecular Sequence Data
- Pharmaceutical Preparations
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single-Stranded Conformational
- Sequence Analysis, DNA
- Steroid 16-alpha-Hydroxylase
- Steroid Hydroxylases