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Article

Genetic alterations of the MYH gene in gastric cancer.

Oncogene - 2 Sept 2004

Kim Chang Jae, Cho Yong Gu, Park Cho Hyun, Kim Su Young, Nam Suk Woo, Lee Sug Hyung, Yoo Nam Jin, Lee Jung Young, Park Won Sang

Abstract excerpt

Increased oxygen free radicals produced in gastric mucosa by H. pylori induce DNA damage and lead to dyspalsia and gastric cancers. However, only a small percentage of individuals that carry H. pylori develop gastric cancer, indicating that other factors are involved. We have screened a set of 95 sporadic gastric cancers for mutations and allele loss of the DNA glycosylase MYH gene, which excises adenine...

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Identifiers

PMID: 15273732
DOI: 10.1038/sj.onc.1207574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Genetic alterations of the MYH gene in gastric cancer.PMID 15273732Read ↗

Role of MYH polymorphisms in sporadic colorectal cancer in China: a case-control, population-based study.Semantic proximity Read ↗

A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus.Semantic proximity Read ↗

Alterations of the base excision repair gene MUTYH in sporadic colorectal cancer.Semantic proximity Read ↗

Identification of MYH mutation carriers in colorectal cancer: a multicenter, case-control, population-based study.Semantic proximity Read ↗

Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study.Semantic proximity Read ↗

Role of inherited defects of MYH in the development of sporadic colorectal cancer.Semantic proximity Read ↗

Germline mutations and polymorphic variants in MMR, E-cadherin and MYH genes associated with familial gastric cancer in Jiangsu of China.Semantic proximity Read ↗

Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer.Semantic proximity Read ↗

Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations.Semantic proximity Read ↗

Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics.Semantic proximity Read ↗

The role of MYH and microsatellite instability in the development of sporadic colorectal cancerSemantic proximity Read ↗

Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.Semantic proximity Read ↗

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