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Article

Role of inherited defects of MYH in the development of sporadic colorectal cancer.

Genes, chromosomes & cancer - 1 May 2004

Kambara Takeshi, Whitehall Vicki L J, Spring Kevin J, Barker Melissa A, Arnold Sven, Wynter Coral V A, Matsubara Nagahide, Tanaka Noriaki, Young Joanne P, Leggett Barbara A, Jass Jeremy R

Abstract excerpt

Biallelic germ-line variants of the 8-hydroxyguanine repair gene MYH have been associated with multiple colorectal adenomas that display somatic G:C-->T:A transversions in APC. However, the effect of single germ-line variants has not been widely studied. To examine the relationship between monoallelic MYH variants and susceptibility to sporadic colorectal cancer (CRC), 92 cases of sporadic CRC, 19 cases of...

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PMID: 15034862
DOI: 10.1002/gcc.20011

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Role of inherited defects of MYH in the development of sporadic colorectal cancer.PMID 15034862Read ↗

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Role of MYH polymorphisms in sporadic colorectal cancer in China: a case-control, population-based study.Semantic proximity Read ↗

Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations in<i>MYH</i>Semantic proximity Read ↗

Comprehensive analysis of the contribution of germline MYH variation to early-onset colorectal cancer.Semantic proximity Read ↗

Microsatellite stable colorectal cancers in clinically suspected hereditary nonpolyposis colorectal cancer patients without vertical transmission of disease are unlikely to be caused by biallelic germline mutations in MYH.Semantic proximity Read ↗

Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics.Semantic proximity Read ↗

Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study.Semantic proximity Read ↗

Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea.Semantic proximity Read ↗

Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations.Semantic proximity Read ↗

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Pathological features of colorectal carcinomas in MYH‐associated polyposisSemantic proximity Read ↗

Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.Semantic proximity Read ↗

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