Article
Identification of MYH mutation carriers in colorectal cancer: a multicenter, case-control, population-based study.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Mar 2007
Balaguer Francesc, Castellví-Bel Sergi, Castells Antoni, Andreu Montserrat, Muñoz Jenifer, Gisbert Javier P, Llor Xavier, Jover Rodrigo, de Cid Rafael, Gonzalo Victòria, Bessa Xavier, Xicola Rosa M, Pons Elisenda, Alenda Cristina, Payá Artemio, Piqué Josep M
Abstract excerpt
BACKGROUND & AIMS: Whereas it has conclusively been demonstrated that biallelic MutY human homolog (MYH) mutations confer a significant risk for colorectal cancer (CRC), the influence of monoallelic mutations remains controversial. Characterization of MYH-associated CRC is critical to identify individuals who might benefit from preventive strategies. This prospective, multicenter, case-control, population-based...
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