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Article

Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.

Journal of the National Cancer Institute - 3 Nov 2004

Croitoru Marina E, Cleary Sean P, Di Nicola Nando, Manno Michael, Selander Teresa, Aronson Melyssa, Redston Mark, Cotterchio Michelle, Knight Julia, Gryfe Robert, Gallinger Steven

Abstract excerpt

The MutY human homologue (MYH) gene encodes a member of the base excision repair pathway that is involved in repairing oxidative damage to DNA. Two germline MYH gene mutations that result in Myh proteins containing amino acid substitutions Y165C and G382D (hereafter called the Y165C and G382D mutations) are associated with adenomatous poly-posis and colorectal cancer among patients from several European...

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PMID: 15523092
DOI: 10.1093/jnci/djh288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk.PMID 15523092Read ↗

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Increased frequency of disease-causing MYH mutations in colon cancer families.Semantic proximity Read ↗

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Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study.Semantic proximity Read ↗

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