Article
A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus.
Carcinogenesis - 1 Oct 2004
Tao Hong, Shinmura Kazuya, Hanaoka Tomoyuki, Natsukawa Syusuke, Shaura Kozo, Koizumi Yoichi, Kasuga Yoshio, Ozawa Takachika, Tsujinaka Toshimasa, Li Zhongyou, Yamaguchi Satoru, Yokota Jun, Sugimura Haruhiko, Tsugane Shoichiro
Abstract excerpt
The MYH gene encodes a DNA glycosylase involved in the excision repair of adenines paired with 8-hydroxyguanines, a major component of oxidative DNA damage, and bi-allelic germline MYH mutations have been reported to predispose individuals to multiple colorectal adenomas and carcinoma. To determine whether the MYH gene is involved in gastric carcinogenesis, we examined blood specimens from 20 Japanese familial...
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