Article
Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics.
Diseases of the colon and rectum - 1 Oct 2007
Bouguen Guillaume, Manfredi Sylvain, Blayau Martine, Dugast Catherine, Buecher Bruno, Bonneau Dominique, Siproudhis Laurent, David Véronique, Bretagne Jean-François
Abstract excerpt
PURPOSE: Recent literature reports that several digestive diseases are associated with mutations in the base excision repair gene MYH. This study was designed to establish the prevalence of germ-line MYH mutations in a series of 56 consecutive patients with no detectable APC mutation and describe the phenotype of those with MYH mutations. METHODS: MYH mutations were screened by DNA sequencing after polymerase...
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