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Article

Alterations of the base excision repair gene MUTYH in sporadic colorectal cancer.

Oncology reports - 1 Aug 2012

Kuno Takashi, Matsubara Nagahide, Tsuda Satoshi, Kobayashi Masayoshi, Hamanaka Mie, Yamagishi Daisuke, Tsukamoto Kiyoshi, Yamano Tomoki, Noda Masafumi, Ikeuchi Hiroki, Kim Sanghyuk, Tamura Kazuo, Tomita Naohiro

Abstract excerpt

The base excision repair gene MUTYH encodes glycosylase which removes adenine residues mispaired with 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHG). Biallelic germline mutations of the MUTYH gene are known to cause multiple colorectal adenomas including polyposis and cancer, mostly due to G:C➝T:A t...

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Source

Identifiers

PMID: 22641385
DOI: 10.3892/or.2012.1836

Genes

MUTYH
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22641385-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Alterations of the base excision repair gene MUTYH in sporadic colorectal cancer.PMID 22641385Read ↗

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Heterozygous deleterious MUTYH variants as a driver for tumorigenesisSemantic proximity Read ↗

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Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population.Semantic proximity Read ↗

Role of MUTYH in human cancer.Semantic proximity Read ↗

A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants.Semantic proximity Read ↗

Characteristics of MUTYH variants in Japanese colorectal polyposis patients.Semantic proximity Read ↗

Germline haploinsufficiency for the base excision repair gene <i>MUTYH</i> causes mutational signature SBS18 in multiple tumour types, specifically leading to an increased risk of colorectal cancerSemantic proximity Read ↗

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MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNASemantic proximity Read ↗

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