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Article

Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer.

The Journal of pathology - 1 Nov 2011

Shinmura Kazuya, Goto Masanori, Suzuki Masaya, Tao Hong, Yamada Hidetaka, Igarashi Hisaki, Matsuura Shun, Maeda Matsuyoshi, Konno Hiroyuki, Matsuda Tomonari, Sugimura Haruhiko

Abstract excerpt

The MUTYH gene encodes a DNA glycosylase that can initiate the excision repair of adenine mispaired with 8-hydroxyguanine (8OHG) and is responsible for a susceptibility to multiple colorectal adenomas and carcinomas. To determine whether the MUTYH gene is involved in gastric carcinogenesis, we first examined the expression level of MUTYH in gastric cancer. The reduced expression of MUTYH mRNA transcript was...

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Source

Identifiers

PMID: 21826668
DOI: 10.1002/path.2953

Genes

MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer.PMID 21826668Read ↗

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