Article
Germline mutations and polymorphic variants in MMR, E-cadherin and MYH genes associated with familial gastric cancer in Jiangsu of China.
International journal of cancer - 1 Dec 2006
Zhang Yuanying, Liu Xiaorong, Fan Yimei, Ding Jianhua, Xu Ailing, Zhou Xuefu, Hu Xu, Zhu Ming, Zhang Xiaomei, Li Suping, Wu Jianzhong, Cao Haixia, Li Jintian, Wang Yaping
Abstract excerpt
Germline mutations in MSH2, MLH1, E-cadherin and MutY (MYH) genes have been implicated in the occurrence of gastric cancer (GC). Epidemiological investigation was performed by recruiting patients with GC onset during 2002 in Jiangsu province, China. We identified suspected hereditary GC patients...
Topics
- Adaptor Proteins, Signal Transducing
- Cadherins
- Carrier Proteins
- China
- Chromatography, High Pressure Liquid
- DNA Glycosylases
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- MutL Protein Homolog 1
- MutS Homolog 2 Protein
- Nuclear Proteins
- Polymerase Chain Reaction