The role of MYH and microsatellite instability in the development of sporadic colorectal cancer

Abstract excerpt

Biallelic germline mutations in MYH are associated with colorectal neoplasms, which develop through a pathway involving somatic inactivation of APC. In this study, we investigated the incidence of the common MYH mutations in an Australian cohort of sporadic colorectal cancers, the clinicopathological features of MYH cancers, and determined whether inactivation of mismatch repair and base excision repair (BER)...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Colorectal Cancer Screening and Detection
• Share to Colorectal Cancer Treatments and Studies
• Share to Genetic factors in colorectal cancer