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Article

Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375.

The EMBO journal - 18 Aug 2004

Schulz Stefan, Mayer Dana, Pfeiffer Manuela, Stumm Ralf, Koch Thomas, Höllt Volker

Abstract excerpt

Morphine is a poor inducer of micro-opioid receptor (MOR) internalization, but a potent inducer of cellular tolerance. Here we show that, in contrast to full agonists such as [D-Ala(2)-MePhe(4)-Gly-ol]enkephalin (DAMGO), morphine stimulated a selective phosphorylation of the carboxy-terminal residue 375 (Ser(375)). Ser(375) phosphorylation was sufficient and required for morphine-induced desensitization of MOR....

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Identifiers

PMID: 15272312
DOI: 10.1038/sj.emboj.7600334
PMCID: PMC514508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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