Article
Replacement of threonine 394 by alanine facilitates internalization and resensitization of the rat mu opioid receptor.
Molecular pharmacology - 1 Feb 1999
Wolf R, Koch T, Schulz S, Klutzny M, Schröder H, Raulf E, Bühling F, Höllt V
Abstract excerpt
Signaling of G protein-coupled receptors is terminated by phosphorylation of intracellular serine and threonine residues. Resensitization of these receptors requires internalization and subsequent dephosphorylation. We have recently shown that the resensitization rate of the rat micro opioid rece...
Topics
- Alanine
- Amino Acid Substitution
- Analgesics, Opioid
- Animals
- Cyclic AMP
- Endocytosis
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- Enkephalins
- Gene Expression Regulation, Neoplastic
- Mutation
- Rats
- Receptors, Cell Surface
- Receptors, Opioid, mu
- Threonine
- Tumor Cells, Cultured