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Article

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization.

Science signaling - 17 Jul 2018

Miess Elke, Gondin Arisbel B, Yousuf Arsalan, Steinborn Ralph, Mösslein Nadja, Yang Yunshi, Göldner Martin, Ruland Julia G, Bünemann Moritz, Krasel Cornelius, Christie MacDonald J, Halls Michelle L, Schulz Stefan, Canals Meritxell

Abstract excerpt

G protein receptor kinases (GRKs) and β-arrestins are key regulators of μ-opioid receptor (MOR) signaling and trafficking. We have previously shown that high-efficacy opioids such as DAMGO stimulate a GRK2/3-mediated multisite phosphorylation of conserved C-terminal tail serine and threonine residues, which facilitates internalization of the receptor. In contrast, morphine-induced phosphorylation of MOR is...

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Source

Identifiers

PMID: 30018083
DOI: 10.1126/scisignal.aas9609

Genes

GRK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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