Article
Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization.
Biochemistry - 9 May 2000
Deng H B, Yu Y, Pak Y, O'Dowd B F, George S R, Surratt C K, Uhl G R, Wang J B
Abstract excerpt
Determining which domains and amino acid residues of the mu opioid receptor are phosphorylated is critical for understanding the mechanism of mu opioid receptor phosphorylation. The role of the C-terminus of the receptor was investigated by examining the C-terminally truncated or point-mutated mu opioid receptors in receptor phosphorylation and desensitization. Both wild-type and mutated receptors were stably...
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