Article
T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Oct 2016
Wang Xiao-Fei, Barbier Elisabeth, Chiu Yi-Ting, He Yi, Zhan Jia, Bi Guo-Hua, Zhang Hai-Ying, Feng Bo, Liu-Chen Lee-Yuan, Wang Jia Bei, Xi Zheng-Xiong
Abstract excerpt
The etiology and pathophysiology underlying opioid tolerance and dependence are still unknown. Because mu opioid receptor (MOR) plays an essential role in opioid action, many vulnerability-related studies have focused on single nucleotide polymorphisms of MOR, particularly on A118G. In this study, we found that a single-point mutation at the MOR T394 phosphorylation site could be another important susceptive...
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