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Article

Morphine promotes phosphorylation of the human delta-opioid receptor at serine 363.

European journal of pharmacology - 20 Sept 2005

Navratilova Edita, Eaton Miriam C, Stropova Dagmar, Varga Eva V, Vanderah Todd W, Roeske William R, Yamamura Henry I

Abstract excerpt

After prolonged stimulation, the delta-opioid receptor becomes desensitized by regulatory mechanisms such as receptor phosphorylation, internalization and down-regulation. In this study, we demonstrate that morphine treatment causes phosphorylation of S363 in the C-terminus of the human delta-opioid receptor. Morphine-mediated phosphorylation reached 53+/-8% of maximum deltorphin II-mediated phosphorylation....

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Identifiers

PMID: 16135360
DOI: 10.1016/j.ejphar.2005.07.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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