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Article

Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo.

Pharmacological research - 1 May 2017

Kibaly Cherkaouia, Lin Hong-Yiou, Loh Horace H, Law Ping-Yee

Abstract excerpt

The development of tolerance to morphine, one of the most potent analgesics, in the management of chronic pain is a significant clinical problem and its mechanisms are poorly understood. Morphine exerts its pharmacological effects via the μ-opioid receptor (MOR). Tolerance is highly connected to G-protein-coupled receptors (GPCR) phosphorylation and desensitization increase. Because morphine desensitization...

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Identifiers

PMID: 28179123
DOI: 10.1016/j.phrs.2017.01.033
PMCID: PMC5392433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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