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Article

Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal.

Neuron - 6 Dec 2001

Finn A K, Whistler J L

Abstract excerpt

Morphine is unusual in its failure to promote robust desensitization and endocytosis of the mu opioid receptor (MOR), processes that for many receptors contribute directly to tolerance. This apparent paradox has led us to revise the idea that receptor desensitization and endocytosis are solely responsible for tolerance and withdrawal to morphine, and instead test the hypothesis that these side effects occur due...

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Source

Identifiers

PMID: 11738029
DOI: 10.1016/s0896-6273(01)00517-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal.PMID 11738029Read ↗

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