Article
Two C-terminal amino acids, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1 receptors.
Cellular signalling - 1 May 2006
Wang Hung-Li, Kuo Yo-Li, Hsu Chia-Yu, Huang Pei-Chen, Li Allen H, Chou An-Hsun, Yeh Tu-Hsueh, Chen Ying-Ling
Abstract excerpt
Various cellular signaling pathways induced by nociceptin activation of ORL1 (opioid receptor-like 1 receptor) develop homologous desensitization. Multiple lines of evidence suggest that agonist-induced phosphorylation of serine (Ser)/threonine (Thr) residues at intracellular carboxyl tail leads to homologous desensitization of G protein-coupled receptors. In the present study, we investigated the functional role...
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