Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2009

He Li, Kim Joseph A, Whistler Jennifer L

Abstract excerpt

Growing evidence shows that trafficking of the mu-opioid receptor (MOR) is a critical process in functional recovery from desensitization following activation and plays important roles in morphine tolerance and dependence largely because of the failure of morphine to promote such trafficking. However, morphine tolerance and dependence are believed to be mediated by multiple mechanisms, including well-documented...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Drug Tolerance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endocytosis

Share to Gene Knock-In Techniques

Share to Mice, Inbred C57BL

Share to Morphine

Share to Pain Measurement

Share to Receptors, Opioid, mu

Source

Open in PubMed Open full text

Identifiers

PMID: 19679639
DOI: 10.1096/fj.09-133223
PMCID: PMC2812043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor.PMID 19679639Read ↗

Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal.Semantic proximity Read ↗

Naltrexone, Naloxone, Morphine, and Fentanyl Pharmacologically Chaperone a Mutant μ-Opioid Receptor via an Endoplasmic Reticulum Exit Site-Dependent Pathway.Semantic proximity Read ↗

Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons.Semantic proximity Read ↗

Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons.Semantic proximity Read ↗

Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.Semantic proximity Read ↗

Glucocorticoid receptors in dopaminoceptive neurons, key for cocaine, are dispensable for molecular and behavioral morphine responses.Semantic proximity Read ↗

Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375.Semantic proximity Read ↗

Functional characterization of human variants of the mu-opioid receptor gene.Semantic proximity Read ↗

Opioid receptors.Semantic proximity Read ↗

The mu-opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in mu-opioid receptor knockout mice.Semantic proximity Read ↗

Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment.Semantic proximity Read ↗

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.