Article
Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1.
The Journal of biological chemistry - 24 Dec 2004
Kayser Ernst-Bernhard, Sedensky Margaret M, Morgan Phil G, Hoppel Charles L
Abstract excerpt
The long-lived mutant of Caenorhabditis elegans, clk-1, is unable to synthesize ubiquinone, CoQ(9). Instead, the mutant accumulates demethoxyubiquinone(9) and small amounts of rhodoquinone(9) as well as dietary CoQ(8). We found a profound defect in oxidative phosphorylation, a test of integrated mitochondrial function, in clk-1 mitochondria fueled by NADH-linked electron donors, i.e. complex I-dependent...
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