Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of different ubiquinones on lifespan in Caenorhabditis elegans.

Mechanisms of ageing and development - 1 Jun 2009

Yang Yu-Ying, Gangoiti Jon A, Sedensky Margaret M, Morgan Phil G

Abstract excerpt

Ubiquinone (UQ, Coenzyme Q, CoQ) transfers electrons from complexes I and II to complex III in the mitochondrial electron transport chain. Depending on the degree of reduction, UQ can act as either a pro- or an antioxidant. Mutations disrupting ubiquinone synthesis increase lifespan in both the nematode (clk-1) and the mouse (mclk-1). The mutated nematodes survive using exogenous ubiquinone from bacteria, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Respiration

Share to Hydrogen Peroxide

Share to Longevity

Share to Mitochondrial Proteins

Share to Reactive Oxygen Species

Share to Ubiquinone

Source

Open in PubMed Open full text

Identifiers

PMID: 19428456
DOI: 10.1016/j.mad.2009.03.003
PMCID: PMC2684812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of different ubiquinones on lifespan in Caenorhabditis elegans.PMID 19428456Read ↗

Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes.Semantic proximity Read ↗

Effects of the mitochondrial respiratory chain on longevity in C. elegans.Semantic proximity Read ↗

Quinones in long-lived clk-1 mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1.Semantic proximity Read ↗

Ubiquinone is necessary for Caenorhabditis elegans development at mitochondrial and non-mitochondrial sites.Semantic proximity Read ↗

Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage.Semantic proximity Read ↗

Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.Semantic proximity Read ↗

The role of DMQ(9) in the long-lived mutant clk-1.Semantic proximity Read ↗

The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans.Semantic proximity Read ↗

A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Restoration of the behavioral rates and lifespan in clk-1 mutant nematodes in response to exogenous coenzyme Q(10).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.