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Article

Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2010

Butler Jeffrey A, Ventura Natascia, Johnson Thomas E, Rea Shane L

Abstract excerpt

The Caenorhabditis elegans mitochondrial (Mit) mutants have disrupted mitochondrial electron transport chain (ETC) functionality, yet, surprisingly, they are long lived. We have previously proposed that Mit mutants supplement their energy needs by exploiting alternate energy production pathways normally used by wild-type animals only when exposed to hypoxic conditions. We have also proposed that longevity in the...

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Identifiers

PMID: 20732954
DOI: 10.1096/fj.10-162941
PMCID: PMC2992375

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