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Article

Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice.

The Journal of biological chemistry - 24 Jul 2009

Lapointe Jérôme, Stepanyan Zaruhi, Bigras Eve, Hekimi Siegfried

Abstract excerpt

Although there is a consensus that mitochondrial function is somehow linked to the aging process, the exact role played by mitochondria in this process remains unresolved. The discovery that reduced activity of the mitochondrial enzyme CLK-1/MCLK1 (also known as COQ7) extends lifespan in both Caenorhabditis elegans and mice has provided a genetic model to test mitochondrial theories of aging. We have recently...

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Identifiers

PMID: 19478076
DOI: 10.1074/jbc.M109.006569
PMCID: PMC2740461

Genes

COQ7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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