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Article

Early mitochondrial dysfunction in long-lived Mclk1+/- mice.

The Journal of biological chemistry - 19 Sept 2008

Lapointe Jérôme, Hekimi Siegfried

Abstract excerpt

Reduced activity of CLK-1/MCLK1 (also known as COQ7), a mitochondrial enzyme that is necessary for ubiquinone biosynthesis, prolongs the lifespan of nematodes and mice by a mechanism that is distinct from that of the insulin signaling pathway. Here we show that 2-fold reduction of MCLK1 expression in mice reveals an additional function for the protein, as this level of reduction does not affect ubiquinone levels...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18635541
DOI: 10.1074/jbc.M803287200
PMCID: PMC3258865

Genes

COQ7

Provenance

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