Article
The role of DMQ(9) in the long-lived mutant clk-1.
Mechanisms of ageing and development - 1 Jan 2000
Yang Yu-Ying, Vasta Valeria, Hahn Sihoun, Gangoiti Jon A, Opheim Elyce, Sedensky Margaret M, Morgan Phil G
Abstract excerpt
INTRODUCTION: Ubiquinone (UQ) is a redox active lipid that transfers electrons from complex I or II to complex III in the electron transport chain (ETC). The long-lived Caenorhabditis elegans mutant clk-1 is unable to synthesize its native ubiquinone, and accumulates high amounts of its precursor, 5-demethoxyubiquinone-9 (DMQ(9)). In clk-1, complexes I-III activity is inhibited while complexes II-III activity is...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Electron Transport Chain Complex Proteins
- Longevity
- Mitochondria
- Mutation
- Ubiquinone