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Article

Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage.

Genetics - 1 Jun 2010

Van Raamsdonk Jeremy Michael, Meng Yan, Camp Darius, Yang Wen, Jia Xihua, Bénard Claire, Hekimi Siegfried

Abstract excerpt

On the basis of the free radical and rate of living theories of aging, it has been proposed that decreased metabolism leads to increased longevity through a decreased production of reactive oxygen species (ROS). In this article, we examine the relationship between mitochondrial energy metabolism and life span by using the Clk mutants in Caenorhabditis elegans. Clk mutants are characterized by slow physiologic...

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Identifiers

PMID: 20382831
DOI: 10.1534/genetics.110.115378
PMCID: PMC2881137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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