Article
Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.
The Journal of biological chemistry - 16 Mar 2001
Miyadera H, Amino H, Hiraishi A, Taka H, Murayama K, Miyoshi H, Sakamoto K, Ishii N, Hekimi S, Kita K
Abstract excerpt
Mutations in the clk-1 gene of Caenorhabditis elegans result in an extended life span and an average slowing down of developmental and behavioral rates. However, it has not been possible to identify biochemical changes that might underlie the extension of life span observed in clk-1 mutants, and...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Electron Transport
- Helminth Proteins
- Mitochondria
- Mutation
- Ubiquinone