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Article

CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans.

The EMBO journal - 1 Apr 1999

Felkai S, Ewbank J J, Lemieux J, Labbé J C, Brown G G, Hekimi S

Abstract excerpt

Mutations in the clk-1 gene of the nematode Caenorhabditis elegans result in an average slowing of a variety of developmental and physiological processes, including the cell cycle, embryogenesis, post-embryonic growth, rhythmic behaviors and aging. In yeast, a CLK-1 homologue is absolutely requir...

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Identifiers

PMID: 10202142
DOI: 10.1093/emboj/18.7.1783
PMCID: PMC1171264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10202142-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans.PMID 10202142Read ↗

Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice.Semantic proximity Read ↗

Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging.Semantic proximity Read ↗

Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1.Semantic proximity Read ↗

A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans.Semantic proximity Read ↗

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The role of mitochondria in the life of the nematode, Caenorhabditis elegans.Semantic proximity Read ↗

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Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging.Semantic proximity Read ↗

No reduction of energy metabolism in Clk mutants.Semantic proximity Read ↗

Early mitochondrial dysfunction in long-lived Mclk1+/- mice.Semantic proximity Read ↗

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