Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C. elegans knockouts in ubiquinone biosynthesis genes result in different phenotypes during larval development.

BioFactors (Oxford, England) - 1 Jan 2005

Gavilán Angela, Asencio Claudio, Cabello Juan, Rodríguez-Aguilera Juan C, Schnabel Ralf, Navas Plácido

Abstract excerpt

Ubiquinone is an essential molecule in aerobic organisms to achieve both, ATP synthesis and antioxidant defence. Mutants in genes responsible of ubiquinone biosynthesis lead to non-respiring petite yeast. In C. elegans, coq-7/clk-1 but not coq-3 mutants live longer than wild type showing a 'slowed' phenotype. In this paper we demonstrate that absence in ubiquinone in coq-1, coq-2 or coq-8 mutants lead to larval...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Gene Deletion

Share to Longevity

Share to Pharynx

Share to Ubiquinone

Source

Identifiers

PMID: 16873927
DOI: 10.1002/biof.5520250104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C. elegans knockouts in ubiquinone biosynthesis genes result in different phenotypes during larval development.PMID 16873927Read ↗

Coenzyme Q supports distinct developmental processes in Caenorhabditis elegans.Semantic proximity Read ↗

Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Ubiquinone is necessary for Caenorhabditis elegans development at mitochondrial and non-mitochondrial sites.Semantic proximity Read ↗

Molecular genetics of ubiquinone biosynthesis in animals.Semantic proximity Read ↗

Comparison of a coq7 deletion mutant with other respiration-defective mutants in fission yeast.Semantic proximity Read ↗

Mouse homologue of coq7/clk-1, longevity gene in Caenorhabditis elegans, is essential for coenzyme Q synthesis, maintenance of mitochondrial integrity, and neurogenesis.Semantic proximity Read ↗

Promotion of growth by Coenzyme Q10 is linked to gene expression in C. elegans.Semantic proximity Read ↗

Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1.Semantic proximity Read ↗

Molecular mechanism of maternal rescue in the clk-1 mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes.Semantic proximity Read ↗

Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity.Semantic proximity Read ↗

Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.