Article
Ubiquinone is necessary for Caenorhabditis elegans development at mitochondrial and non-mitochondrial sites.
The Journal of biological chemistry - 18 Jan 2002
Hihi Abdelmadjid K, Gao Yuan, Hekimi Siegfried
Abstract excerpt
Ubiquinone (UQ) is a lipid co-factor that is involved in numerous enzymatic processes and is present in most cellular membranes. In particular, UQ is a crucial electron carrier in the mitochondrial respiratory chain. Recently, it was shown that clk-1 mutants of the nematode worm Caenorhabditis elegans do not synthesize UQ(9) but instead accumulate demethoxyubiquinone (DMQ(9)), a biosynthetic precursor of UQ(9)...
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