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Article

DNA replication and transcription direct a DNA strand bias in the process of targeted gene repair in mammalian cells.

Journal of cell science - 1 Aug 2004

Brachman Erin E, Kmiec Eric B

Abstract excerpt

The repair of point mutations can be directed by modified single-stranded DNA oligonucleotides and regulated by cellular activities including homologous recombination, mismatch repair and transcription. Now, we report that DNA replication modulates the gene repair process by influencing the frequency with which either DNA strand is corrected. An SV40-virus-based system was used to investigate the role of DNA...

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Identifiers

PMID: 15265980
DOI: 10.1242/jcs.01250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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