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Article

DNA-directed mutations. Leading and lagging strand specificity.

Annals of the New York Academy of Sciences - 18 May 1999

Sinden R R, Hashem V I, Rosche W A

Abstract excerpt

The fidelity of replication has evolved to reproduce B-form DNA accurately, while allowing a low frequency of mutation. The fidelity of replication can be compromised, however, by defined order sequence DNA (dosDNA) that can adopt unusual or non B-DNA conformations. These alternative DNA conformations, including hairpins, cruciforms, triplex DNAs, and slipped-strand structures, may affect enzyme-template...

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PMID: 10415482
DOI: 10.1111/j.1749-6632.1999.tb08878.x

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