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Article

Targeted mutagenesis of SV40 DNA induced by UV light.

Nature - 1 Jan 2000

Bourre F, Sarasin A

Abstract excerpt

UV light is a potent mutagen in most living cells, but molecular analysis of its mode of action in animal cells has not been possible because of the high complexity of the cell genome. Therefore, we have used simian virus 40 (SV40) as a biological probe to study the mutagenic effect of UV-irradiation at the molecular level. A thermosensitive SV40 mutant of the large T antigen (tsA58), which is defective at high...

Topics

Animals
Antigens, Polyomavirus Transforming
Base Sequence
DNA Repair
DNA, Viral
Genes
Genes, Viral
Mutation
Ultraviolet Rays
Viral Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 6554450
DOI: 10.1038/305068a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6554450-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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