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Article

In vitro (CTG)*(CAG) expansions and deletions by human cell extracts.

The Journal of biological chemistry - 19 Apr 2002

Panigrahi Gagan B, Cleary John D, Pearson Christopher E

Abstract excerpt

The mechanism of disease-associated (CTG)*(CAG) expansion may involve DNA replication slippage, replication direction, Okazaki fragment processing, recombination, or repair. A length-dependent bias for expansions is observed in humans affected by a trinucleotide repeat-associated disease. We developed an assay to test the effect of replication direction on (CTG)*(CAG) instabilities incurred during in vitro (SV40)...

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Identifiers

PMID: 11832482
DOI: 10.1074/jbc.M109761200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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