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Article

Strand bias in targeted gene repair is influenced by transcriptional activity.

Molecular and cellular biology - 1 Jun 2002

Liu Li, Rice Michael C, Drury Miya, Cheng Shuqiu, Gamper Howard, Kmiec Eric B

Abstract excerpt

Modified single-stranded DNA oligonucleotides can direct nucleotide exchange in Saccharomyces cerevisiae. Point and frameshift mutations are corrected in a reaction catalyzed by cellular enzymes involved in various DNA repair processes. The present model centers on the annealing of the vector to one strand of the helix, followed by the correction of the designated base. The choice of which strand to target is a...

Topics

Amino Acid Sequence
Base Sequence
DNA Repair
DNA, Recombinant
Drug Resistance, Fungal
Gene Expression
Green Fluorescent Proteins
Hygromycin B
Luminescent Proteins
Models, Genetic
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Plasmids

Recombinant Fusion Proteins

Saccharomyces cerevisiae

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 11997519
DOI: 10.1128/MCB.22.11.3852-3863.2002
PMCID: PMC133839

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