Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The involvement of replication in single stranded oligonucleotide-mediated gene repair.

Nucleic acids research - 1 Jan 2006

Huen Michael S Y, Li Xin-tian, Lu Lin-Yu, Watt Rory M, Liu De-Pei, Huang Jian-Dong

Abstract excerpt

Targeted gene repair mediated by single-stranded oligonucleotides (SSOs) has great potential for use in functional genomic studies and gene therapy. Genetic changes have been created using this approach in a number of prokaryotic and eukaryotic systems, including mouse embryonic stem cells. However, the underlying mechanisms remain to be fully established. In one of the current models, the 'annealing-integration'...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mismatch Repair
Share to DNA Polymerase III

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to DNA Replication

Share to DNA, Single-Stranded

Share to Escherichia coli Proteins

Share to Oligonucleotides

Share to Replication Origin

Source

Open in PubMed Open full text

Identifiers

PMID: 17088285
DOI: 10.1093/nar/gkl852
PMCID: PMC1693898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The involvement of replication in single stranded oligonucleotide-mediated gene repair.PMID 17088285Read ↗

Lambda red recombineering in Escherichia coli occurs through a fully single-stranded intermediate.Semantic proximity Read ↗

Identification of factors influencing strand bias in oligonucleotide-mediated recombination in Escherichia coli.Semantic proximity Read ↗

Double-stranded break can be repaired by single-stranded oligonucleotides via the ATM/ATR pathway in mammalian cells.Semantic proximity Read ↗

Extensive trimming of short single-stranded DNA oligonucleotides during replication-coupled gene editing in mammalian cells.Semantic proximity Read ↗

Targeted correction of a chromosomal point mutation by modified single-stranded oligonucleotides in a GFP recovery system.Semantic proximity Read ↗

Highly efficient deletion method for the engineering of plasmid DNA with single-stranded oligonucleotides.Semantic proximity Read ↗

Reliable method for generating double-stranded DNA vectors containing site-specific base modifications.Semantic proximity Read ↗

Mode of action of RNA/DNA oligonucleotides: progress in the development of gene repair as a therapy for alpha(1)-antitrypsin deficiency.Semantic proximity Read ↗

Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.Semantic proximity Read ↗

Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration.Semantic proximity Read ↗

Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination.Semantic proximity Read ↗

On the mutagenicity of homologous recombination and double-strand break repair in bacteriophage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.