Article
Error-prone replication of ultraviolet-irradiated simian virus 40 in carcinogen-treated monkey kidney cells.
Biochimie - 1 Jan 2000
Sarasin A, Bourre F, Benoit A
Abstract excerpt
To analyze the molecular mechanism of mutagenesis in carcinogen-treated mammalian cells, we developed a model system composed of various simian virus 40 (SV40) mutants as a biological probe to detect inducible DNA repair and mutagenesis in carcinogen-treated monkey kidney cells (CV1-P). Results have shown that treatment of cells with UV-light, acetoxy-acetyl-aminofluorene, or mitomycin C, increases the...
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