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Article

Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes.

Immunology and cell biology - 1 Apr 2004

Steele Edward J, Franklin Andrew, Blanden Robert V

Abstract excerpt

The history and current development of the reverse transcriptase model of somatic hypermutation (RT-model) is reviewed with particular reference to the genesis of strand-biased mutation signatures in rearranged immunoglobulin variable genes (V(D)J). The recent disagreement in the field as to whether strand bias really exists or not has been critically analysed and the confusion traced to the putative presence, in...

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Identifiers

PMID: 15061776
DOI: 10.1046/j.0818-9641.2004.01224.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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