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Article

Double-strand breaks and tumorigenesis.

Trends in cell biology - 1 Nov 2001

Pierce A J, Stark J M, Araujo F D, Moynahan M E, Berwick M, Jasin M

Abstract excerpt

The establishment of connections between biochemical defects and clinical disease is a major goal of modern molecular genetics. In this review, we examine the current literature that relates defects in the two major DNA double-strand-break repair pathways--homologous recombination and nonhomologous end-joining--with the development of human tumors. Although definitive proof has yet to be obtained, the current...

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PMID: 11684443
DOI: 10.1016/s0962-8924(01)02149-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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