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Article

In vitro model for DNA double-strand break repair analysis in breast cancer reveals cell type-specific associations with age and prognosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2016

Deniz Miriam, Kaufmann Julia, Stahl Andreea, Gundelach Theresa, Janni Wolfgang, Hoffmann Isabell, Keimling Marlen, Hampp Stephanie, Ihle Michaela, Wiesmüller Lisa

Abstract excerpt

Dysfunction of homologous recombination is a common denominator of changes associated with breast cancer-predisposing mutations. In our previous work, we identified a functional signature in peripheral blood lymphocytes from women who were predisposed that indicated a shift from homologous recombination to alternative, error-prone DNA double-strand break (DSB) repair pathways. To capture both hereditary and...

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PMID: 27494941
DOI: 10.1096/fj.201600453R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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