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Article

The power of DNA double-strand break (DSB) repair testing to predict breast cancer susceptibility.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2012

Keimling Marlen, Deniz Miriam, Varga Dominic, Stahl Andreea, Schrezenmeier Hubert, Kreienberg Rolf, Hoffmann Isabell, König Jochem, Wiesmüller Lisa

Abstract excerpt

Most presently known breast cancer susceptibility genes have been linked to DSB repair. To identify novel markers that may serve as indicators for breast cancer risk, we performed DSB repair analyses using a case-control design. Thus, we examined 35 women with defined familial history of breast and/or ovarian cancer (first case group), 175 patients with breast cancer (second case group), and 245 healthy women...

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PMID: 22278937
DOI: 10.1096/fj.11-200790

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